Cystic fibrosis also affects the digestive system. The sticky mucus also provides an ideal environment for bacterial growth. The Cystic Fibrosis Foundation is a leading healthcare nonprofit organization like no other. ; Turner, P.E. Clofazimine inhalation suspension for the aerosol treatment of pulmonary nontuberculous mycobacterial infections. 1) The CFTR protein is missing or non-functional so chloride ions are not secreted into the mucus. Please let us know what you think of our products and services. ; van Duin, D.; et al. Sample exam questions - genetics - Edexcel . A step by step guide is then used to describe the sequence of events that result in mucus which is motile and can be moved by the wafting action of the cilia in healthy individuals. First assessment: 2017. You are accessing a machine-readable page. This drug is ; Harris, M.; Blay, J.Y. For all these reasons, the identification of new therapeutic strategies that can support or refine the scarce antibiotic options available today is an imperative issue to be addressed. Clear and accessible assessments. Please note that many of the page functionalities won't work as expected without javascript enabled. Combined host- and pathogen-directed therapy for the control of. The lesson PowerPoints are highly detailed, and along with their accompanying worksheets, they have been planned at length to contain a wide range of engaging tasks which cover the following A-level Biology content found in topics 2, 3 and 6 of the course: ; Britigan, B.E. It states that 'the rate of diffusion is proportional to both the surface area and . [, The identification and evolution of antimicrobial compounds used as therapeutic means was a revolutionary discovery. ; Riethmuller, J. Gaseous nitric oxide to treat antibiotic resistant bacterial and fungal lung infections in patients with cystic fibrosis: A phase I clinical study. ; Brown-Elliott, B.A. IVF used if have family history of CF as tested at 8 cells before insertion to avoid abortion I am doing this case study so people have an idea of what is cystic fibrosis in detail and what people think of it. P1b 1c Very big and very small numbers H PBworks. This topic considers the following biological principles through the context of the genetic disease cystic fibrosis: the properties of and transport of materials, across cell membranes and gas exchange surfaces, DNA structure and replication, protein synthesis, enzymes and monohybrid inheritance through the context of the genetic disease cystic fibrosis. Gibson, L.E. ), as well as hybrid nanoparticles (micelles, nanocarriers, carbon nanotubes and nano-sponges, polymerosomes, etc. Cystic fibrosis is a Genetic Disease, this means its inherited from there parents. ; Lucidi, V.; et al. Answers > Biology > A Level > Article Explain how cystic fibrosis affects digestion, gas exchange and reproduction. Antimicrobial properties of, Bogdanovski, K.; Chau, T.; Robinson, C.J. An official ATS/IDSA statement: Diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. This lesson describes how the expression of a gene mutation impairs the functioning of the organ systems in people with cystic fibrosis. Prepare for GCSE Biology examinations. This research was funded by the Italian Cystic Fibrosis Foundation, grant number FFC#18/2021 (adopted by Delegazione FFC Ricerca di Codogno e Piacenza, Delegazione FFC Ricerca di Rovigo, Delegazione FFC Ricerca di Belluno, Nonno Nanni Latteria Montello), and FFC#5/2022 (adopted by: Gruppo di sostegno FFC Ricerca Miriam ColomboOspedaletti; Gruppo di sostegno FFC Ricerca di GradoGorizia; Gruppo di sostegno FFC Ricerca di Benevento; Delegazione FFC Ricerca di Monterotondo Roma; Delegazione FFC Ricerca di Vigevano; Delegazione FFC Ricerca di Trieste; Delegazione FFC Ricerca di Sassari Castelsardo; Delegazione FFC Ricerca di Moncalvo; Delegazione FFC Ricerca di Lecce). ; DaSilva, R.A.; de Souza, A.C.; Mortari, M.R. ; Rogasi, P.G. 7 Cystic fibrosis is a life-threatening condition that can affect many different parts of the body. ; Naehrlich, L.; Stahl, M.; Rohrbach, A.; Drescher, M.; Minso, R.; Ringshausen, F.C. nucleus most exciting work published in the various research areas of the journal. Miller, C.; Miller, M.; McMullin, B.; Regev, G.; Serghides, L.; Kain, K.; Road, J.; Av-Gay, Y. J. Mol. Bar-Oz, M.; Meir, M.; Barkan, D. Virulence-associated secretion in, Briken, V.; Miller, J.L. Intracellular pathogens evolved to infect, colonise, and duplicate within host cells, managing to hide from the host immune system [, This lack of appropriate classical therapies has different causes, including antimicrobial resistance (AMR) which could have several mechanisms, such as the misuse of antimicrobials in both the healthcare and veterinary sectors. Finally, AMR can also be induced by the need for long periods of treatment to reach the effective circulating dose, with an inevitable increase in side effects [, To fight the antimicrobial-resistant and emerging pathogen, Nitric oxide (NO), a highly reactive vaso- and broncho-dilator molecule is part of the natural defence mechanism of the immune system [, Endogenous NO is formed by nitric oxide synthases (NOSs) using L-arginine as a precursor [, It is noteworthy that CF individuals are characterised in the lungs by a low NO production [, Other preclinical studies have observed a broad-spectrum antibacterial function after the administration of gaseous NO at a high dose (160 p.p.m.) Judson, I.; Radford, J.A. It is caused by a recessive mutation in a gene located on chromosome 7. Cystic Fibrosis is UKs most common life threatening inherited disease [1]. * Adaptations of the mammalian lung for rapid gaseous exchange ; Lin, H.C.; Liu, C.Y. Cystic fibrosis is a genetic disorder caused by a recessive allele. * A gene as a sequence of bases on DNA that codes for a sequence of amino acids ; Peterson, A.M.; Mashek, C.M. * Understand how the rate of diffusion can be calculated using Fick's Law of Diffusion Cystic fibrosis: A clinical view. ; Yu, C.T. Antimicrobial reactive oxygen and nitrogen species: Concepts and controversies. registered in England (Company No 02017289) with its registered office at Building 3, ; Carrasco-Anton, N.; Esteban, J. ; De Santis, F.; Henrici De Angelis, L.; Ciciriello, F.; DAndrea, M.M. Interestingly, the latter was able to eradicate four cases of paediatric dysentery in 1919 in Paris using the administration of a phage preparation [, Therapeutic bacteriophages are pathogen-specific and safe for human tissues [. Munoz-Egea, M.C. Cystic fibrosis affects over 7,500 people in the UK [2]. Make a quick list of five to ten clothing items that you've thought about owning. If you're ready to pass your Edexcel A-Level Biology exams, become a member now to get complete access to our entire library of revision materials. interesting to readers, or important in the respective research area. ; Cheung, G.Y.C. Tes Global Ltd is CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. r)>62}OkGS5M>E5NxAP$~xmL4JxUE1q\f" at 7-9 weeks The 20 lesson PowerPoints and accompanying resources contain a wide range of activities which cover the following topic 2 specification points: ; Rimkus, M.; Montgomery, F.; Lucas da Silva, J.; et al. This can put a person with cystic fibrosis at risk of getting bacterial chest infections. ; Gaillard, J.L. Castellani, C.; Assael, B.M. Again, the students are guided through the events that lead to the depletion of the apical surface liquid and the cilia being unable to move the viscous mucus. * A gene is a sequence of bases on DNA that codes for the amino acid sequence of a polypeptide CFTR is a type of protein classified as an ABC (ATP-binding cassette) transporter or traffic ATPase. Luthra, S.; Rominski, A.; Sander, P. The Role of Antibiotic-Target-Modifying and Antibiotic-Modifying Enzymes in, Pasipanodya, J.G. I am constantly thinking of new ways to engage a student with a topic and try to implement that in the design of the lessons. What happens if there is excess water in the airways? - false results can provide incorrect information, 10 weeks of pregnancy or 8 weeks after conception, at 15-17 weeks As you can see the percentage is falling. All articles published by MDPI are made immediately available worldwide under an open access license. Report this resourceto let us know if it violates our terms and conditions. Your rating is required to reflect your happiness. Daley, C.L. Thanks very much for sharing this It is a great help. ; et al. ; Daher, W.; Kremer, L. Verapamil Improves the Activity of Bedaquiline against, Vesenbeckh, S.; Schnfeld, N.; Roth, A.; Bettermann, G.; Krieger, D.; Bauer, T.T. 2.17 (ii): Understand the implications of prenatal genetic screening ; Santos, B.P. ; Gomes, M.S. 2.13 (ii): Understand patterns of inheritance, including the interpretation of genetic pedigree diagrams, in the context of monohybrid inheritance 1) Thick mucus blocks the pancreatic duct. My arguments for the abortion of a cystic fibrosis child are that the children that have cystic fibrosis and they are in a womens womb and the parents know they do is I think they should get the abortion because the kid will have a long suffering life and the parents will go through hard times. ; Kuo, H.P. 3.9 (i): Know that a locus is the location of genes on a chromosome with cystic fibrosis who are infected with these bacteria. ; et al. Spallanzani, University of Pavia, 27100 Pavia, Italy. In this context, drugs already used against, To date, there is not a consolidated standard drug regimen to treat MABSC infections, although the US Cystic Fibrosis Foundation and the European Cystic Fibrosis Society published consensus recommendations for the management of NTM in patients with CF [. - Higher level of the protein trypsinogen in the blood - Newborn Blood Spot Screening Programme, - Carrier testing offered to those with a family history of CF 2.17 (i): Understand the uses of genetic screening, including the identification of carriers, pre-implantation genetic diagnosis (PGD) and prenatal testing, including amniocentesis and chorionic villus sampling GCSE 9 1 Combined Science Biology Chemistry Physics AQA. 1) Chloride ions are pumped into the epithelial cell causing a concentration gradient and the CFTR channel protein opens 2) Chloride ions diffuse into the mucus through the CFTR protein 3) This closes the ENaC 4) The build up of chloride ions creates an electrical gradient so sodium ions diffuse into the mucus between the gaps in epithelial cells Edexcel A Level Biology 2d - Cystic Fibrosis. Tes Global Ltd is ; Sangen, J.; Wuest, A.W. - 10-20% of a mother's DNA is the embryos, 'the greatest good for the greatest number', traditional virtues: justice, prudence (wisdom), temperance (moderation), fortitude (courage), faith, hope and clarity, A-Level Biology Edexcel A (Salters) : 1 - Lif, AQA A Level Chemistry - Organic Synthesis, AQA A Level Chemistry - Iodine Clock Reaction, AQA A Level Psychology - Relationships d - Fi. Yaacoby-Bianu, K.; Gur, M.; Toukan, Y.; Nir, V.; Hakim, F.; Geffen, Y.; Bentur, L. Compassionate Nitric Oxide adjuvant treatment of persistent. ; Colmant, A.; Rodriguez-Villalobos, H. Targeting bedaquiline mycobacterial efflux pump to potentially enhance therapy in, Viljoen, A.; Raynaud, C.; Johansen, M.D. 3.12: Understand how cells become specialised through differential gene expression, producing active mRNA leading to synthesis of proteins, which in turn control cell processes or determine cell structure in animals and plants, including the lac operon Due to the detailed content of this lesson, it is estimated that it will take in excess of 3 hours of allocated A-level teaching time to cover. People in the respective research area mutation in a gene located on chromosome 7 genetic... Various research areas of the page functionalities wo n't work as expected without javascript enabled the and..., M.R M. ; Barkan, D. Virulence-associated secretion in, Briken, V. Miller... Big and very small numbers H PBworks much for sharing this it is caused by a recessive.! 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